How It Works
See the genetic logic behind our Translation-Coupled Certificate™.
Need Help?
Contact our science team for custom plasmid design support.
Configure Your Order
1Strain Selection
Includes genomic integration of stress sensors, logic gates, and the latch mechanism.
Integrated Catcheater Features
2Plasmid Customization
3Contact Information
Plasmid Map
Configuration Status
You will receive a quote within 24h.
The Problem
Type-2 cheater cells sabotage protein production by creating toxic, misfolded proteins.
- Eliminates cheater populations
- >10x productive cell enrichment
How It Works
Native stress sensors detect proteotoxic stress and trigger elimination of non-productive cells.
- Dual stress sensors (σ32, σE/Cpx)
- Irreversible elimination latch
The Silent Killer
In standard fermentation, 'Bad Clones' stop producing your protein to grow fast. They take over the tank, crashing your yield.
1. The Snitch
Sensing the Betrayal
Our genomic sensors monitor the cell's workload. If a cell stops producing your protein to save energy, the stress levels drop instantly. The Snitch knows.
2. The Latch
Genetic Memory
Once the default is detected, a tyrosine recombinase flips a DNA switch. This isn't temporary—it's a permanent, heritable mark of shame.
3. The Enforcer
Immediate Termination
Marked cells triggers the production of endolysins. The 'Cheater' cell is lysed (popped) from within. Only productive 'Good Clones' survive.
Pure Yield
Automatic QC
The result? A fermentation tank filled 100% with high-producing cells. No more crash. No more evolution. Just protein.
Available Kits & Modules
Select high-performance components to build your custom strain.
The Snitch - Core Sensor
Instant proteotoxicity detection with fluorescent output. The gold standard for quality control.
Smart Backbone (pCatch)
Metabolically optimized plasmid backbone for stability. Reduces burden by 40%.
The Enforcer Module
Autonomously eliminates non-productive or mutated cells (Kill Switch).
Toxic Control Strain
Positive control strain for calibrating sensor response.
Road to Resilience
We are rapidly advancing from lab-bench verification to industrial integration.
Proof of Concept (TRL 3)
Successful demonstration of the "Catcheater" circuit in lab-scale E. coli cultures. Validation of cheater detection mechanism.
Prototype Validation (TRL 4)
Optimization of genetic circuit stability. achieving >95% plasmid retention in high-stress mock fermentation environments.
Pilot Studies (TRL 6)
Collaboration with industrial partners to test "Catcheater" strains in 50L+ bioreactors. Real-world yield comparison.
Commercial Launch
Release of the "Catcheater" Engineering Kit and licensing model for CDMOs and pharmaceutical manufacturers.
Built by Scientists
We are a team of synthetic biologists determined to solve the reliability crisis in biomanufacturing.
