Deep dives into synthetic biology, fermentation optimization, and the science behind Catcheater.
Plasmid-bearing cells grow 15-20% slower than their plasmid-free counterparts. In a standard bioreactor, this differential growth rate allows 'cheater' cells to overtake the culture in just 40 generations. We analyze the math behind the takeover.
Amir M. Cheraghali
Co-Founder & Lead Scientist
How do you distinguish a stressed producer from a lazy cheater? Our 'Snitch' sensor detects the heat-shock response of protein burden, while the 'Enforcer' checks for plasmid retention. A deep dive into the AND-gate logic of pCatch.
Sogand Azadeh
Co-Founder & Research Lead
Industrial fermentation requires stability over hundreds of bacterial generations. In a recent pilot with a Top 5 Pharma partner, the Catcheater system maintained >99% plasmid retention for 120 hours of continuous culture.
Sogand Azadeh
Co-Founder & Research Lead
Continuous biomanufacturing is the holy grail of efficiency, but genetic drift makes it nearly impossible. We explore how 'Cheater' mutations accumulate over time and why traditional selection methods fail after generation 60.
Amir M. Cheraghali
Co-Founder & Lead Scientist
Regulatory pressure from the FDA and EMA is mounting to remove antibiotics from the manufacturing chain. How will the industry adapt when the primary method of plasmid retention is banned?
Amir M. Cheraghali
Co-Founder & Lead Scientist
A single crashed fermentation tank can cost upwards of €250,000 in lost media, time, and opportunity cost. We break down the unit economics of 'Stability Assurance' and why it pays for itself in a single run.
Sogand Azadeh
Co-Founder & Research Lead