Catcheater is a proprietary biological quality control circuit. It serves as an embedded "immune system" for your bioreactors, autonomously identifying and neutralizing non-productive mutant cells ("cheaters") that compromise yield stability.
Detailed genetic sequences, promoter architectures, and specific mechanism of action data are proprietary and available only under NDA. The documentation below provides a functional overview of the system's capabilities.
By constantly purging low-performing variants, Catcheater extends the productive phase of fermentation, allowing for longer continuous runs without genetic drift.
No external inducers or manual intervention required. The sensor network is constitutively active and responds dynamically to intracellular stress signals.
The system integrates into standard industrial pipelines with zero disruption.
Select your chassis and target protein. We engineer the specific "Snitch" sensor tuned to your product's metabolic burden.
Standard transformation protocols apply. The system is delivered on a high-stability backbone compatible with common industrial strains.
Run your fermentation as usual. The Catcheater circuit runs in the background, ensuring population homogeneity.
We currently support major E. coli production strains (B and K-12 derivatives). Contact us for yeast and mammalian cell inquiries.
Cheater cells are lysed and their biomass is recycled by the productive population, effectively converting burden capability into yield.
The sensor circuit is designed to be extremely lightweight. In comparative studies, the burden of maintaining the circuit is negligible compared to the yield gains from improved population stability.
Yes. Our pCatch-v2 backbone includes an auxotrophic complementation module, allowing for antibiotic-free fermentation when used with compatible host strains.
Absolutely. The system has been validated from microplate scale up to 10,000L industrial bioreactors. The mechanism relies on intracellular sensing, which is volume-independent.
For standard proteins, we can ship a custom sensor strain within 2-3 weeks. Complex pathways may require a 4-6 week optimization pilot.
The system uses standard GRAS (Generally Recognized As Safe) biological parts. It does not introduce novel toxins or allergens, simplifying the regulatory pathway for your final product.